Feb

14

First blinded study of venous insufficiency prevalence in multiple sclerosis shows promising results

Filed Under News, Research 

ScienceDaily Feb. 14, 2010 — More than 55 percent of multiple sclerosis patients participating in the initial phase of the first randomized clinical study to determine if persons with MS exhibit narrowing of the extracranial veins, causing restriction of normal outflow of blood from the brain, were found to have the abnormality.

The results were reported February 10 by neurology researchers at the University at Buffalo.

When the 10.2 percent of subjects in which results were border line were excluded, the percentage of affected MS patients rose to 62.5 percent, preliminary results show, compared to 25.9 percent of healthy controls.

These preliminary results are based on the first 500 participants in the Combined Transcranial and Extracranial Venous Doppler Evaluation CTEVD study, which began at UB in April 2009. Investigators are planning to examine 500 additional subjects, who will be assessed in the second phase of the study with more advanced diagnostic tools. Complete data on the first 500 will be presented at the American Academy of Neurology meeting in April.

Robert Zivadinov, MD, PhD, UB associate professor of neurology and principal investigator on the study, says he is “cautiously optimistic and excited” about the preliminary data. Zivadinov directs the Buffalo Neuroimaging Analysis Center BNAC, located in Kaleida Health’s Buffalo General Hospital, where the study is being conducted.

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